| Whole cohort N = 40 | Lower Crs N = 16 | Higher Crs N = 24 | p value |
---|---|---|---|---|
Anthropometric measures | Â | Â | Â | Â |
Male Sex (n-%) | 30 (75) | 10 (62.5) | 20 (83.3) | 0.1360 |
Weight (kg) | 86.1 ± 17.8 | 79.1 ± 10.2 | 90.1 ± 20.3 | 0.0416 |
Height (m) | 1.72 ± 0.08 | 1.68 ± 0.09 | 1.73 ± 0.07 | 0.0959 |
Predicted body weight (kg) | 67.6 ± 7.6 | 65.1 ± 8.5 | 69.2 ± 6.7 | 0.1041 |
Body-mass index (kg/m2) | 29.1 ± 5.6 | 27.9 ± 5.3 | 29.9 ± 5.7 | 0.2549 |
Age (years) | 68.0 ± 8.9 | 71.8 ± 6.6 | 65.5 ± 9.6 | 0.0277 |
Comorbidities | Â | Â | Â | Â |
Hypertension (n-%) | 29 (72.5) | 11 (68.8) | 18 (75.0) | 0.6650 |
Diabetes (n-%) | 5 (12.5) | 1 (6.25) | 4 (16.7) | 0.9524 |
Renal failure (n-%) | 3 (7.5) | 1 (6.25) | 2 (8.33) | 0.0601 |
Cardiac failure (n-%) | 3 (7.5) | 1 (6.25) | 2 (8.33) | 0.0601 |
Respiratory disease (n-%) | 6 (15.0) | 2 (12.5) | 4 (16.7) | 0.1307 |
ICU severity scores | Â | Â | Â | Â |
SAPS II | 37.1 ± 6.5 | 38.6 ± 6.2 | 36.2 ± 6.6 | 0.2583 |
PaO2/FiO2 at ICU admission (mmHg) | 174 ± 87 | 163 ± 79 | 182 ± 93 | 0.5207 |
Parameters at enrolment | Â | Â | Â | Â |
Temperature (C°) | 36.6 ± 0.2 | 36.5 ± 0.2 | 36.6 ± 0.2 | 0.4319 |
RASS | − 4 ± 0 | − 4 ± 0 | − 4 ± 0 | > 0.999 |
FiO2 | 0.58 ± 0.08 | 0.64 ± 0.07 | 0.54 ± 0.06 |  < 0.0001 |
Tidal volume (mL) | 488 ± 81 | 396 ± 38 | 550 ± 18 |  < 0.0001 |
Tidal volume/PBW (mL/kg) | 7.2 ± 1.2 | 6.1 ± 1.1 | 8.0 ± 0.8 |  < 0.0001 |
Respiratory rate (1/min) | 18.5 ± 3.76 | 22.6 ± 2.0 | 15.8 ± 1.2 |  < 0.0001 |
Minute ventilation (L/min) | 8.76 ± 0.73 | 8.91 ± 0.83 | 8.66 ± 0.66 | 0.2883 |
PEEP (cmH2O) | 9.3 ± 1.6 | 10.3 ± 1.9 | 8.8 ± 1.0 | 0.0024 |
Outcome | Â | Â | Â | Â |
ICU Non-survivors (n-%) | 13 (32.5) | 9 (56.3) | 4 (16.7) | 0.0090 |
Hospital length of stay (days) | 32.0 ± 12.9 | 31.7 ± 15.0 | 32.1 ± 12.9 | 0.9182 |
ICU length of stay (days) | 24.0 ± 11.3 | 26.2 ± 12.1 | 22.5 ± 10.8 | 0.3129 |