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Table 3 Modifications to intermittent dialytic techniques (IHD and PIRRT) to prevent further ABI

From: Acute kidney injury in neurocritical care

Modification item

Recommendation

Dialyzer

Use membranes with small surface area

blood flow

If using IHD or PIRRT, consider using lower blood flows of < 300 mL/min

Dialysate flow

Consider using lower dialysate flow rates for IHD/PIRRT (< 600 mL/min) and lower effluent rates for CRRT (20 mL/kg/h)

Ultrafiltration Rate

Avoid high net ultrafiltration rates (< 10 mL/kg/h for IHD and < 2 mL/kg/h for CRRT)

Vasopressor

Consider using vasopressors to keep MAP and CPP goals

Dialysate temperature

Cool dialysate to 35 °C

Electrolytes

Use higher dialysate sodium concentration

Use lower dialysate bicarbonate concentration

Use higher dialysate calcium concentration

Frequency

Daily dialysis to minimize peaks and troughs in serum BUN levels

  1. The table summarizes possible modifications to RRT prescription parameters in patients with ABI [113, 114]
  2. ABI acute brain injury, BUN blood urea nitrogen, CPP cerebral perfusion pressure, CRRT continuous renal replacement therapy, IHD intermittent hemodialysis, MAP mean arterial pressure, PIRRT prolonged intermittent renal replacement therapy