Table 2 Proposed targets for control of systemic causes of secondary brain injury
From: The spectrum of sepsis-associated encephalopathy: a clinical perspective
Variable | Proposed target | Comments |
|---|---|---|
MAP | 65–80 mmHg | A higher MAP target (≥ 80mmHg) is not associated with reduced mortality [61, 63] A higher MAP target is associated with higher RASS scores during ICU stay [64] |
PaO2 | 80–120 mmHg | Hyperoxia is associated with increased mortality [65] |
PaCO2 | 35–45 mmHg | Hypercapnia (> 45 mmHg) is associated with an increased risk of SAE [8] |
Temperature | 36–38.3°C | Fever (> 38.4 °C) is associated with higher mortality [66, 67] |
Natremia | 135–145 mmol/L | Hypernatremia is associated with an increased risk of SAE [8] |
Glycemia | 5–10 mmol/L | Hypoglycemia (< 3 mmol/l) and hyperglycemia (> 10 mmol/l) are associated with an increased risk of SAE [8] |
Hemoglobin |  > 7g/dL | A higher transfusion threshold (> 9g/dL) is not associated with decreased mortality [68, 69] |