Brain tissue oxygen monitoring in traumatic brain injury—part II: isolated and combined insults in relation to outcome

Table 4 Cerebral physiological insults in relation to unfavourable outcome and mortality—multiple logistic outcome regressions

Variables	Unfavourable outcome		Mortality
Variables	OR (95% CI)	p	OR (95% CI)	p
Absolute CPP insults
Age (years)	1.03 (1.01–1.05)	< *0.001*	1.04 (1.01–1.06)	*0.004*
GCS (scale)	0.84 (0.77–0.93)	< *0.001*	0.88 (0.78–0.99)	*0.04*
ICP > 20 mmHg (%)	1.01 (0.99–1.02)	0.29	1.03 (1.01–1.05)	*0.009*
PRx > 0.30 (%)	1.02 (1.00–1.04)	0.06	1.05 (1.02–1.07)	< *0.001*
CPP < 60 mmHg (%)	1.04 (0.99–1.09)	0.09	1.04 (0.99–1.10)	0.10
PbtO₂ < 15 mmHg (%)	1.02 (1.00–1.04)	*0.048*	1.00 (0.97–1.02)	0.77
Autoregulatory CPPopt insults
Age (years)	1.03 (1.01–1.05)	< *0.001*	1.03 (1.01–1.06)	*0.006*
GCS (scale)	0.85 (0.78–0.93)	< *0.001*	0.91 (0.80–1.01)	0.08
ICP > 20 mmHg (%)	1.01 (0.99–1.02)	0.32	1.02 (1.00–1.04)	*0.02*
PRx > 0.30 (%)	1.02 (1.00–1.04)	0.09	1.04 (1.02–1.07)	< *0.001*
∆CPPopt < −5 mmHg (%)	1.03 (1.00–1.06)	*0.03*	1.05 (1.02–1.09)	*0.002*
PbtO₂ < 15 mmHg (%)	1.02 (1.00–1.04)	0.07	0.99 (0.97–1.02)	0.59

Bold and italics indicate statistical significance
CPP models, favourable outcome (AUROC (95% CI) = 0.76 (0.70–0.82), AIC = 270, Nagelkerke = 0.26) and mortality (AUROC (95% CI) = 0.83 (0.76-0.90), AIC = 181, Nagelkerke = 0.40)
CPPopt models, favourable outcome (AUROC (95% CI) = 0.76 (0.70–0.82), AIC = 266, Nagelkerke = 0.27) and mortality (AUROC (95% CI) = 0.84 (0.78-0.91), AIC = 173, Nagelkerke = 0.44)
AIC akaike information criterion, CI confidence interval, CPP cerebral perfusion pressure, CPPopt optimal CPP, GCS Glasgow Coma Scale, ICP intracranial pressure, OR odds ratio, PbtO₂ partial brain tissue oxygenation, PRx pressure reactivity index

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