Skip to main content

Table 3  Multivariable associations between systolic and diastolic pressure 0–6 h post arrest and survival

From: Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study

 

Survival to hospital discharge with favorable neurologic outcomea

Survival to hospital discharge

 

Overall (N = 693)

Relative risk (95% CI)

P value

Relative risk (95% CI)

P value

Post-arrest systolic threshold (0–6 h)c

  

 < .001

 

 < .001

 Above (> 10th percentile)

352 (50.8%)

1.22 (1.10, 1.35)

 

1.21 (1.10, 1.33)

 

 Below—inclusive (≤ 10th percentile)

341 (49.2%)

Reference

 

Reference

 

 Post-arrest diastolic threshold (0–6 h)c

  

 < .001

 

 < .001

 Above (> 50th percentile)

346 (49.9%)

1.27 (1.15, 1.40)

 

1.23 (1.12, 1.34)

 

 Below—inclusive (≤ 50th percentile)

347 (50.1%)

Reference

 

Reference

 

Controlling also for intra-arrest diastolic pressure (met target: yes, no)b,c(N = 227)

 Post-arrest systolic threshold (0–6 h)c

  

0.500

 

0.769

  Above (> 10th percentile)

100 (44.1%)

1.06 (0.90, 1.25)

 

1.02 (0.88, 1.19)

 

  Below—inclusive (≤ 10th percentile)

127 (55.9%)

Reference

 

Reference

 

 Post-arrest diastolic threshold (0–6 h)c

  

0.586

 

0.636

  Above (> 50th percentile)

121 (53.3%)

1.05 (0.89, 1.24)

 

1.04 (0.89, 1.20)

 

  Below—inclusive (≤ 50th percentile)

106 (46.7%)

Reference

 

Reference

 

Interaction between intra- and post-arrest diastolic pressure (N = 227)

  

0.736

 

0.332

 Above intra-arrest target and above post-arrest threshold

112 (16.2%)

1.21 (0.79, 1.87)

 

1.27 (0.81, 1.98)

 

 Above intra-arrest target and below post-arrest threshold

94 (13.6%)

1.19 (0.77, 1.84)

 

1.27 (0.80, 2.00)

 

 Below intra-arrest target and above post-arrest threshold

9 (1.3%)

1.33 (0.80, 2.19)

 

1.51 (0.92, 2.46)

 

 Below intra-arrest target and below post-arrest threshold

12 (1.7%)

Reference

 

Reference

 
  1. aFavorable neurologic outcome was defined as no more than moderate disability or no worsening from baseline Pediatric Cerebral Performance Category (PCPC). Baseline PCPC represents subject status prior to the event leading to hospitalization
  2. bAll models control for illness category and pre-arrest hypotension. Two, noted above, also control for whether the intra-arrest diastolic blood pressure target was met
  3. c Target intra-arrest diastolic pressure was ≥ 25 mmHg for subjects < 1 year old or ≥ 30 for subjects ≥ 1 year. Post-arrest systolic or diastolic thresholds
  4. defined as the minimum recorded systolic or diastolic blood pressure in the time period ≤ the 10th or 50th percentile for age, sex, and height, respectively
Back to article page

Critical Care

ISSN: 1364-8535