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Table 3 In vitro susceptibility and breakpoints of echinocandins for the main Candida species

From: Critical appraisal beyond clinical guidelines for intraabdominal candidiasis

 

Caspofungin [53]

Micafungin [52]

Anidulafungin [52]

 

MIC90

CLSI

EUCASTa

MIC90

CLSI

EUCAST

MIC90

CLSI

EUCAST

C. albicans

0.03

 ≥ 1

 

0.015

 ≥ 1

 > 0.016

0.06

 ≥ 1

 > 0.032

C. glabrata

0.06

 ≥ 0.5

 

0.03

 ≥ 0.25

 > 0.032

0.12

 ≥ 0.5

 > 0.064

C. parapsilosis

0.5

 ≥ 8

 

1

 ≥ 8

 > 2

2

 ≥ 8

 > 4

C. tropicalis

0.06

 ≥ 1

 

0.03

 ≥ 1

N/A

0.06

 ≥ 1

 > 0.064

  1. aIsolates susceptible to anidulafungin and micafungin should be considered susceptible to caspofungin
  2. MIC90 values (mg/L) of echinocandins, CLSI [54] and EUCAST [55] breakpoints for different Candida species
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Critical Care

ISSN: 1364-8535