Table 2 Effects of volume expansion (Upper Panel) and of the increase in norepinephrine (Lower Panel) on hemodynamic variables
Before intervention | After invention | p-value | |
|---|---|---|---|
Volume expansion | |||
MAP–mmHg | 70 [62–79] | 82 [75–101] | < 0.0001 |
DAP–mmHg | 53 [47–62] | 62 [56–73] | 0.003 |
CVP–mmHg | 7 [4–9] | 10 [7–12] | < 0.0001 |
CI–L/min/m2 | 2.57 [2.06–3.01] | 2.91 [2.33–3.54] | 0.0001 |
HR–beats/min | 106 [86–118] | 103 [81–115] | 0.02 |
Blood temperature–°C | 36.9 [36.0–37.6] | 36.8 [35.7–37.3] | < 0.0001 |
Arterial lactate–mmol/L | 3.8 [2.3–4.8] | – | |
Norepinephrine | |||
Rate–µg/kg/min | 0.74 [0.28–1.67] | – | |
Delay between initiation and CRT–hour | 21 [8–33] | – | |
CRT–sec | 5.18 [3.24–7.44] | 4.18 [2.77–5.94] | < 0.0001 |
Increase in the norepinephrine dose | |||
MAP–mmHg | 66 [60–75] | 85 [80–103] | < 0.0001 |
DAP–mmHg | 50 [45–60] | 62 [58–76] | < 0.0001 |
CVP–mmHg | 9 [7–13] | 12 [8–14] | 0.048 |
CI–L/min/m2 | 2.88 [2.00–3.64] | 2.94 [2.38–3.95] | < 0.0001 |
HR–beats/min | 87 [73–103] | 87 [72–98] | 0.59 |
Blood temperature–°C | 37.0 [36.1–37.4] | 36.9 [36.1–37.3] | 0.62 |
Lactate–mmol/L | 2.2 [1.8–3.1] | – | |
Norepinephrine | |||
Rate–µg/kg/min | 0.23 [0.08–0.51] | 0.42 [0.30–0.74] | < 0.0001 |
Delay between initiation and CRT–hour | 58 [15–197] | – | |
CRT–s | 2.73 [1.63–4.88] | 2.34 [1.30–4.10] | 0.008 |