Table 1 Demographic, clinical and outcome characteristics of the cohort by presence or absence of sepsis renal angina (sRAI) fulfillment on Day 1

N (%cohort)

363

223 (61)

140 (39)

–

Age, years

9.6 (3.3–16.3)

10.3 (4.1–16.3)

8.6 (2.2–15.9)

0.06

Male sex, n (%)

187 (52)

106 (48)

81 (58)

0.06

History of Transplant

34 (9)

10 (4)

24 (17)

 < 0.001

Severity of Illness

PRISM III

8 (5–13)

7 (3–10)

12 (8–17)

 < 0.001

PERSEVERE-II Mortality Probability

0.007 (0.007–0.189)

0.007 (0.007–0.019)

0.167 (0.007–0.325)

 < 0.001

Baseline SCr, mg/dl

0.36 (0.24–0.49)

0.38 (0.26–0.52)

0.33 (0.22–0.47)

0.012

Baseline Known, n (%)

205 (56)

127 (57)

78 (56)

0.82

D1 Vasoactive Medications, n (%)

D1 VIS

268 (74)

7.0 (0–18)

138 (62)

4.0 (0–10)

130 (93)

14.5 (6–27.8)

 < 0.001

 < 0.001

D1 Mechanical Ventilation, n (%)

202 (56)

87 (39)

115 (82)

 < 0.001

D1 Fluid Balance (%FB)

3.9 (1.3–7.1)

3.4 (1.1–6.3)

4.9 (1.7–8.9)

0.001

D1 SCr > Baseline

1.3 (0.96–2.1)

1.1 (0.9–1.4)

2.2 (1.3–3.6)

 < 0.001

D1 Platelet Count (× 10³/uL)

153 (70–265)

188 (105–305)

98 (45–170)

 < 0.001

D3 Severe AKI, n (%)

79 (22)

12 (5)

67 (48)

 < 0.001

Relative Risk Severe AKI

–

–

RR 8.9 (5–16)

 < 0.001

D1-7 KRT Use, n (%)

49 (13)

4 (2)

45 (32)

 < 0.001

Relative Risk KRT Use

–

–

RR 18 (6.6–49)

 < 0.001

PICU Free Days

22 (10–26)

25 (19–26)

14.5 (0–23)

 < 0.001

28-day Mortality, n (%)

26 (7.2)

10 (4)

16 (11)

0.013

Relative Risk Mortality

–

–

RR 2.5 (1.2–5.5)

0.013