Table 2 Demographic, clinical and outcome characteristics based on the presence or absence of severe acute kidney injury on day 3

N (%cohort)

284 (78)

79 (22)

–

Age, years

9.6 (3.8–16.3)

10.3 (2.1–16.5)

0.54

Male sex, n (%)

144 (51)

43 (54)

0.56

History of Transplant

16 (6)

18 (23)

 < 0.001

Severity of Illness

PRISM III

8 (4–12)

13 (8–17)

 < 0.001

PERSEVERE-II Mortality Probability

0.007 (0.007–0.167)

0.189 (0.007–0.333)

 < 0.001

Baseline SCr, mg/dl

0.37 (0.26–0.5)

0.30 (0.2–0.46)

0.010

Baseline known, n (%)

149 (52)

56 (71)

0.003

D1 Vasoactive Medications, n (%)

198 (70)

70 (89)

 < 0.001

D1 VIS

5.0 (0–14)

17.0 (5.5–36.5)

 < 0.001

D1 Mechanical Ventilation, n (%)

142 (50)

60 (76)

 < 0.001

D1 Fluid Balance (%FB)

3.5 (1.1–6.5)

4.9 (2.2–9.1)

0.005

D1 SCr > Baseline

1.2 (0.9–1.6)

2.8 (1.7–4.4)

 < 0.001

D1 Platelet Count (× 10³/uL)

172 (88–273)

91 (39–227)

 < 0.001

PICU Free Days

24 (16–26)

4 (0–20)

 < 0.001

28-day Mortality, n (%)

11 (4)

15 (19)

RR 4.9 (2.4–10.2)

 < 0.001

 < 0.001