Table 3 Clinical, demographic and outcome variables and predictive performance of day 1 sepsis renal angina fulfillment (sRAI +) compared to degree of serum creatinine elevation above baseline (D1 SCr > Baseline) and original renal angina fulfillment (RAI +)

D3 Severe AKI, n (%)

67 (48)

71 (28)

 < 0.001

76 (39)

0.11

RR vs. D1 SCr > Baseline + 

RR 1.7 (1.3–2.2)

–

 < 0.001

–

–

RR vs. RAI + 

RR 1.2 (0.96–1.6)

–

–

–

0.11

D3 Severe AKI Prediction

AUROC

0.86 (0.82–0.90)

0.82 (0.76–0.88)

0.19

0.86 (0.82–0.90)

–

Sensitivity, %

85 (75–92)

90 (81–95)

96 (89–99)

Specificity, %

74 (69–79)

36 (30–42)

58 (52–64)

PPV, %

48 (39–56)

28 (23–34)

39 (32–46)

NPV, %

95 (91–97)

93 (86–97)

98 (94–99)

 + LR

3.3 (2.7–4.1)

1.4 (1.3–1.6)

2.3 (2.0–2.7)

-LR

0.2 (0.1–0.4)

0.28 (0.1–0.6)

0.07 (0.02–0.2)

D1-7 KRT Use. n (%)

45 (32)

42 (12)

 < 0.001

46 (24)

0.08

RR vs. D1 SCr > Baseline + 

RR 1.9 (1.3–2.8)

–

 < 0.001

–

–

RR vs. RAI + 

RR 1.4 (0.96–1.9)

–

–

–

0.08

PICU Free Days

14.5 (0–23)

23 (11–26)

 < 0.001

18 (0,24)

0.15

28-day Mortality, n (%)

16 (11)

18 (7)

0.15

20 (10)

0.73

RR vs. D1 SCr > Baseline + 

RR 1.6 (0.8–3)

–

0.15

–

–

RR vs. RAI + 

RR 1.1 (0.6–2.1)

–

–

–

0.73