Fig. 1

Sepsis/trauma patients have persistent fungal dysbiosis and pathobiome. a Schematic study design. b Principal coordinate analysis (PCoA) plots showing differences in beta-diversity (Bray–Curtis dissimilarity) between control, sepsis and trauma cohorts with PERMANOVA p values between cohorts. Beta-diversity differences between same sex-counterparts of sepsis or trauma versus control with associated p values. c Mycobiome alpha-diversity comparing control, sepsis and trauma cohorts represented by Shannon, observed amplicon sequence variants (ASVs), and Chao1 index and alpha-diversity comparing males between cohorts or females between cohorts. Intestinal microbiome microbial composition at the d phylum and e genus level between cohorts and separated by sex. M—males; F—females. Data are presented as mean ± SD. *p < 0.05