Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial

Table 2 Clinical and functional outcomes of all subjects

Clinical outcomes	RIC (N = 37)	Sham-RIC (N = 40)	HR/OR*	p value	Adjusted HR/OR*	Adjusted p
Primary outcome—no. (%)	11 (29.7%)	21 (52.5%)	0.442 (0.213–0.918)	0.029	0.396 (0.187–0.838)^a	0.015
All-cause death	6 (16.2%)	15 (37.5%)	0.341 (0.132–0.880)	0.026	0.333 (0.126–0.881)^a	0.027
Recurrence of AIS	1 (2.7%)	5 (12.5%)	0.160 (0.019–1.373)	0.095	0.116 (0.012–1.124)^a	0.063
Recurrence of AMI	10 (27.0%)	16 (40.0%)	0.516 (0.234–1.138)	0.101	0.483 (0.216–1.018)^a	0.076
3-month functional independence	17 (45.9%)	6 (15.0%)	4.675 (1.582–13.819)	0.005	12.75 (2.104–77.21)^b	0.006
mRSscore
1 month	3 (3–4)	4 (3–4)	–	0.002
3 month	3 (2–4)	4 (3–4)	–	0.004
NIHSS
1 week	3 (0–0.75)	6.5 (2.25–11.75)	–	0.020	–
2 weeks^†	2 (0–5)	6 (1–11)	–	0.012	–

RIC remote ischemic conditioning, HR hazard ratio, OR odd ratio, AIS acute ischemic stroke, AMI acute myocardial infarction, NIHSS National Institutes of Health Stroke Scale, mRS modified Rankin Scale
^aAdjusted for age, admission systolic blood pressure, baseline GRACE score
^bAdjusted for age, sex, admission NHISS score, baseline Grace score.
*The effect of RIC on primary outcomes was depicted as HR, and the effect on 3-month functional independence was shown as OR
^†Four patients suffered death in sham-RIC group within two weeks who were excluded in this analysis

ISSN: 1364-8535