Table 1 Priorities in research to improve trauma therapies in poly trauma

Acute care

Understand (trajectory of) coagulopathy, including the endogenous processes that inactivate coagulation factors and platelet function

Investigate dysregulated immune response

Investigate ways to delay ischemia

Identify point of care biomarkers and diagnostics of dysregulated pathways

Development of a drug discovery programme which (at least) includes blocking of activated protein C and scavenging of damage molecules

Understand the impact of blood product manufacturing methods, storage conditions and donor characteristics on outcome of trauma

Development of a programme aimed at standardization of product manufacturing and storage

Longer term care

Investigate biomarker-guided use of prophylactic antibiotics

Investigate optimal dose and timing of thrombo-prophylaxis

Identify cost-effective rehabilitation programmes

Research methodology

Use of translational models that reflect clinical trauma

Implement acceptation of exception from informed consent

Establish and implement use of a core outcome set

Improve quality of trauma registries including physiologic data

Use of adaptive trial designs to include platform trials

Use of Bayesian analyses