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Table 3 The relationship between enteral nutrition and 28-day mortality

From: Enhanced exclusive enteral nutrition delivery during the first 7 days is associated with decreased 28-day mortality in critically ill patients with normal lactate level: a post hoc analysis of a multicenter randomized trial

 

Unadjusted

Adjusted*

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

Total study population (n = 1332)

 Energy delivery (per 5 kcal/kg)

0.843

0.755–0.941

0.002

0.865

0.768–0.974

0.016

 Protein delivery (per 0.2 g/kg)

0.849

0.759–0.949

0.004

0.868

0.770–0.979

0.021

Subgroup analysis

Lactate concentration ≤ 2 mmol/L (n = 774)

 Energy delivery (per 5 kcal/kg)

0.795

0.675–0.935

0.006

0.804

0.674–0.960

0.016

 Protein delivery (per 0.2 g/kg)

0.801

0.679–0.946

0.009

0.804

0.672–0.962

0.017

Lactate concentration > 2 mmol/L (n = 548)

 Energy delivery (per 5 kcal/kg)

0.915

0.788–1.063

0.247

0.933

0.796–1.095

0.396

 Protein delivery (per 0.2 g/kg)

0.921

0.791–1.072

0.288

0.941

0.800–1.105

0.457

  1. *Adjusted for age, sex, BMI, study interventions, SOFA, and number of co-morbidities