Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups

Gritti, Paolo; Bonfanti, Marco; Zangari, Rosalia; Bonanomi, Ezio; Farina, Alessia; Pezzetti, Giulio; Pelliccioli, Isabella; Longhi, Luca; Di Matteo, Maria; Viscone, Andrea; Lando, Gabriele; Cavalleri, Gaia; Gerevini, Simonetta; Biroli, Francesco; Lorini, Ferdinando Luca

doi:10.1186/s13054-024-04814-5

Critical Care

Table 3 Comparisons of AUC for different age groups

From: Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups

	12-month mortality					12-month unfavorable outcome
	AUC (95% CI)	Optimal cutoff	Sensitivity	Specificity	P value	AUC (95% CI)	Optimal cutoff	Sensitivity	Specificity	P value
All patients 0–85 years (n = 263)
Mean ICP	0.69 (0.61–0.77)	19.45	0.47	0.96	< 0.001	0.61 (0.54–0.68)	16.29	0.35	0.91	0.003
Mean CPP	0.64 (0.56–0.73)	57.24	0.44	0.95	0.999	0.46 (0.48–0.61)	57.62	0.27	0.95	0.886
Mean UL-PRx	0.70 (0.62–0.78)	0.31	0.47	0.98	< 0.001	0.62 (0.55–0.69)	0.28	0.30	0.97	< 0.001
Mean ΔCPPopt	0.62 (0.54–0.71)	1.46	0.61	0.63	0.002	0.59 (0.52–0.66)	0.91	0.61	0.54	0.01
Pediatric group (0–16 y, n = 46)
Mean ICP	0.94 (0.82–1.0)	22.28	0.92	0.97	< 0.001	0.79 (0.65–0.93)	22.28	0.57	1.0	< 0.001
Mean CPP	0.90 (0.75–1.0)	38.59	0.83	1.0	0.999	0.76 (0.59–0.92)	48.93	0.57	1.0	0.999
Mean UL-PRx	0.92 (0.80–1.0)	0.33	0.83	0.97	< 0.001	0.74 (0.58–0.90)	0.32	0.57	1.0	0.002
Mean ΔCPPopt	0.65 (0.38–0.92)	0.45	1.0	0.42	0.175	0.69 (0.52–0.85)	–0.17	1.0	0.42	0.036
Middle group (> 16 and < 70 y, n = 159)
Mean ICP	0.82 (0.72–0.91)	19.63	0.61	0.97	< 0.001	0.66 (0.58–0.74)	15.12	0.43	0.89	< 0.001
Mean CPP	0.78 (0.68–0.89)	59.63	0.61	0.96	0.999	0.58 (0.49–0.67)	62.18	0.33	0.92	0.959
Mean UL-PRx	0.77 (0.66–0.88)	0.29	0.61	0.97	< 0.001	0.62 (0.54–0.71)	0.10	0.56	0.75	0.003
Mean ΔCPPopt	0.65 (0.51–0.79)	1.63	0.64	0.71	0.008	0.54 (0.45–0.64)	4.02	0.19	0.92	0.189
Older group (≥ 70 y, n = 58)
Mean ICP	0.62 (0.47–0.76)	13.67	0.34	0.95	0.074	0.60 (0.42–0.79)	8.21	0.67	0.71	0.188
Mean CPP	0.55 (0.39–0.70)	70.55	0.61	0.70	0.282	0.54 (0.33–0.75)	69.67	0.55	0.71	0.378
Mean UL-PRx	0.50 (0.34–0.65)	–0.05	0.26	0.90	0.483	0.47 (0.22–0.71)	0.11	0.57	0.57	0.396
Mean ΔCPPopt	0.53 (0.37–0.70)	0.85	0.36	0.80	0.665	0.53 (0.27–0.79)	0.93	0.66	0.60	0.403
Adult group (> 16 y, n = 217)
Mean ICP	0.66 (0.58–0.75)	19.45	0.39	0.97	< 0.001	0.60 (0.52–0.67)	14.98	0.36	0.89	0.010
Mean CPP	0.63 (0.54–0.72)	59.63	0.40	0.96	0.999	0.55 (0.47–0.62)	61.0	0.25	0.95	0.867
Mean UL-PRx	0.67 (0.58–0.75)	0.31	0.40	0.99	< 0.001	0.61 (0.54–0.68)	0.10	0.52	0.72	0.003
Mean ΔCPPopt	0.62 (0.53–0.71)	2.59	0.46	0.79	0.003	0.57 (0.49–0.65)	2.10	0.41	0.72	0.041

The middle-aged and older groups constitute the adult cohort of this study (n = 217)
ICP Intra-Cranial Pressure; CPP Cerebral Perfusion Pressure; UL-PRx Ultra-Low-Pressure Reactivity index; ΔCPPopt Delta Cerebral Perfusion Pressure optimal; AUC Area Under Curve; CI Confidence Interval
Bold values for a p-value below the threshold (<0.05)

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