Table 3 Laboratory values of patients with coagulopathic endotype at day 7 by arm of treatment
Laboratory values, median (Q1–Q3) | SoC + Placebo (Ν = 34) | SoC + Anakinra (Ν = 54) | p |
|---|---|---|---|
White blood cells, /mm3 | 8800 (7400 to 12,480) | 8580 (6820 to 10,185) | 0.684 |
Lymphocytes, /mm3 | 720 (535 to 1260) | 1060 (735 to 1560) | 0.003 |
Platelets, /mm3 | 314,000 (247,500 to 422,500) | 363,000 (307,500 to 466,500) | 0.026 |
C-reactive protein, mg/l | 15.2 (6.8 to 51.6) | 6.5 (2.5 to 27.9) | 0.001 |
Interleukin-6, pg/ml | 14.4 (3.4 to 59.2) | 5.1 (1.4 to 14.7) | 0.016 |
Ferritin, ng/ml | 585.8 (355.9 to 889.0) | 490.9 (247.2 to 825.8) | 0.373 |
D-dimers, mg/l | 0.72 (0.38 to 1.62) | 0.81 (0.37 to 1.74) | 0.910 |
Serum soluble uPAR, ng/ml | 8.0 (6.3 to 12.1) | 6.5 (4.7 to 8.4) | < 0.001 |
% Change of lymphocytes at day 7 from baseline | − 17.7 (− 71.8 to 13.3) | − 50.1 (− 97.5 to − 13.1) | 0.020 |
% Change of C-reactive protein at day 7 from baseline | − 71.8 (− 90.9 to − 1.5) | − 91.9 (− 95.6 to − 67.2) | 0.002 |
% Change of interleukin-6 at day 7 from baseline | − 16.8 (− 71.9 to 77.8) | − 49.1 (− 78.3 to 22.2) | 0.136 |
% Change of ferritin at day 7 from baseline | − 8.0 (− 28.7 to 13.1) | − 32.8 (− 47.9 to − 10.4) | 0.010 |
% Change of D-dimers at day 7 from baseline | 32.1 (− 5.0 to 216.7) | 6.6 (− 22.1 to 101.6) | 0.208 |
% Change of suPAR at day 7 from baseline | 20.3 (− 4.6 to 38.6) | − 17.4 (-43.2 to 9.1) | < 0.0001 |