No NV-ICU-AP (n = 802) | NV-ICU-AP (n = 42) | p value | |
---|---|---|---|
Median [Q1; Q3] or n (percentage) | Median [Q1; Q3] or n (percentage) | ||
Baseline characteristics | |||
Age (years) | 70.7 [62.0; 78.1] | 72.3 [67.6; 76.9] | 0.33 |
Male sex, n (%) | 499 (62.2) | 31 (73.8) | 0.13 |
BMI (kg/m2) | 24.9 [20.8; 30.3] | 23.9 [21.2; 30.1] | 0.74 |
SAPS II score | 34.0 [26.0; 42.0] | 38.0 [30.0; 45.0] | 0.05 |
Maximum SOFA Day 1- Day 2 | 4.0 [3.0; 6.0] | 5.0 [3.0; 6.0] | 0.06 |
Hospitalisation before ICU admission (yes), n (%) | 264 (32.9) | 20 (47.6) | 0.05 |
Immunodeficiency (yes), n (%) | 74 (9.2) | 6 (14.3) | 0.28 |
No decrease in consciousness Day 1- Day 2 (Glasgow Coma Scale = 15) | 490 (61.1) | 14 (33.1) | < 0.01 |
MDR bacterial colonization, (yes), n (%) | 47 (5.9) | 3 (7.1) | 0.73 |
COPD severity | |||
Very Severe COPD, n (%) | 173 (21.6) | 1 (2.4) | < 0.01 |
Trigger of the acute exacerbation of COPD | |||
Respiratory infection, n (%) | 524 (65.3) | 29 (69.0) | 0.74 |
Non-infectious respiratory causes, n (%) | 165 (20.6) | 8 (19.0) | |
Cardiac and thromboembolic events, n (%) | 63 (7.9) | 4 (9.5) | |
Others, n (%) | 50 (6.2) | 1 (2.4) | |
Therapeutic limitation | |||
Limitation of therapeutic effort at admission to ICU, (yes) n (%) | 63 (7.9) | 3 (7.1) | 0.87 |
Corticosteroid therapy | |||
Use of corticosteroids therapy at admission, (yes) n (%) | 302 (37.7) | 12 (28.6) | 0.24 |
Antibiotic therapy | |||
Use of antibiotic therapy at admission, (yes) n (%) | 561 (70.0) | 25 (59.5) | 0.15 |
Gastroprotective agents | |||
Use of gastroprotective agents at admission, (yes) n (%) | 411 (51.2) | 22 (52.4) | 0.89 |
Enteral nutrition | |||
Use of enteral nutrition at admission, (yes) n (%) | 99 (12.3) | 10 (23.8) | 0.03 |
Lengths of stay | |||
ICU Length of stay (days) | 6.0 [5.0; 10.0] | 24.5 [14.0; 37.0] | < 0.01 |
Hospital Length of stay (days) | 18.0 [12.0; 30.0] | 37.0 [22.0; 59.0] | < 0.01 |
Mortality | |||
ICU Mortality rate, n (%) | 73 (9.1) | 16 (38.1) | < 0.01 |
Hospital Mortality rate, n (%) | 123 (15.3) | 18 (42.9) | < 0.01 |
Mortality at Day 28, n (%) | 96 (12.0) | 10 (23.8) | 0.02 |
Non-ventilator-associated ICU-acquired pneumonia | |||
Day of first diagnosis of NV-ICU-AP (days in ICU) | – | 6.0 [4.0; 11.0] | |
Day of first diagnosis of NV-ICU-AP (days in hospital) | – | 7.5 [5.0; 16.0] | |
NV-ICU-AP requiring intubation, (yes) n (%) | – | 32 (76.2) |