Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study

Cameron, Lynda K.; Ledwaba-Chapman, Lesedi; Voong, Kieran; Hampson, Geeta; Forni, Lui G.; Seylanova, Nina; Harrington, Dominic J.; Lim, Rosario; Bociek, Aneta; Yanzhong, Wang; Ostermann, Marlies

doi:10.1186/s13054-024-04869-4

Critical Care

Table 2 Baseline characteristics based on kidney function and trajectories (as described in Fig. 1)

From: Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study

Variable	Category	All	Kidney Function at day 5
Variable	Category	All	Normal throughout	Developed new AKI	AKI II/III throughout	Renal recovery from AKI II/III	p-value	Missing %
n		137	52	11	51	23
Age		54 [47, 68]	50 [41, 69]	52 [51, 67]	57 [48, 66]	54 [48, 68]	0.776	0.7
Gender	Male	91 (66)	34 (65)	6 (55)	38 (75)	13 (57)	0.340	–
Gender	Female	46 (34)	18 (35)	5 (45)	13 (25)	10 (43)	0.340	–
Ethnicity	Asian	4 (3)	3 (6)	0	1 (2)	0	0.868	3.6
	Black	9 (7)	2 (4)	0	5 (10)	2 (9)
	Caucasian	118 (86)	43 (83)	11 (100)	43 (84)	21 (91)
	Other	1 (1)	1 (2)	0	0	0
	Missing	5 (4)	3 (6)	0	2 (4)	0
Season	Summer	68 (50)	27 (52)	6 (55)	20 (39)	15 (65)	0.201	0.0
Season	Winter	69 (50)	25 (48)	5 (45)	31 (61)	8 (35)	0.201	0.0
CRP (Day 0) [mg/dL]		123 [54, 253]	97 [53, 144]	117 [84, 300]	161 [68, 305]	110 [43, 218]	0.037	11.7
Serum 25(OH)D on day 0 [nmol/L]		18 [10, 31]	20 [12, 34]	32 [14, 40]	14 [9, 26]	19 [9, 35]	0.076	6.6
Serum 1,25(OH)₂D on day 0 [pmol/L]		50 [28, 68]	54 [33, 69]	63 [36, 106]	41 [26, 58]	36 [26, 56]	0.069	5.1
Calcium (Day 0) [mmol/L]		1.1 [1.1,1.2]	1.1 [1.1,1.2]	1.1 [1.1,1.2]	1.1 [1.1,1.2]	1.1 [1.1,1.2]	0.833	6.6
APACHE II score (on admission)		18 [14, 21]	14 [12, 17]	15 [12, 16]	21 [19, 23]	20 [17, 24]	< 0.001	0.0
SOFA minus renal score (Day 0)		10 [7, 12]	8 [7, 10]	9 [6, 9]	11 [9, 13]	10 [8, 12]	< 0.001	6.6
ICU mortality		25 (18)	4 (7.7)	1 (9)	18 (35.3)	2 (8.7)	0.002	-
Hospital mortality		31 (23)	5 (9.6)	1 (9)	22 (43.1)	3 (13)	< 0.001	1.5
30-day mortality		31 (23)	5 (9.6)	1 (9)	23 (45.1)	2 (8.7)	0.001	5
Length of stay in ICU		14 [8, 23]]	10 [5, 15]	16 [10, 19]	18 [10, 30]	18 [8, 27]	0.010	29

AKI Acute kidney injury, APACHE Acute physiology and chronic health evaluation, CRP C-reactive protein, ICU Intensive Care Unit, SOFA Sequential Organ Failure Assessment
Significant variables are indicated in bold
Results are reported as number (%), mean (%) or median [interquartile range]

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ISSN: 1364-8535

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