Skip to main content

Table 1 Characteristics of the patient cohort used to derive the VOC-ARDS score

From: Breath metabolomics for diagnosis of acute respiratory distress syndrome

 

Certain ARDS labels in AMC

 
 

ARDS (n = 60)

Non-ARDS (n = 190)

P value

Patients characteristics

Age, years mean (SD)

60.2 (13.8)

61.8 (16.1)

0.47

Male, n (%)

45 (75)

130 (68)

0.419

Smoker, n (%)

48 (80)

146 (77)

0.738

BMI, kg/m2 median [IQR]

26.9 [23.7, 30.7]

25.8 [23.0, 30.0]

0.191

Admission characteristics

Admission type, n (%)

  

0.001

Emergency surgical

2 (3.3)

37 (19.5)

 

Medical

54 (90.0)

123 (64.7)

 

Planned surgical

4 (6.7)

30 (15.8)

 

Admission condition, n (%)

Trauma

2 (3.3)

34 (17.9)

0.01

Neurosurgery

2 (3.3)

39 (20.5)

0.003

Shock

1 (1.7)

15 (7.9)

0.157

Extrapulmonary sepsis

3 (5.0)

31 (16.3)

0.044

Pancreatitis

0 (0.0)

3 (1.6)

0.765

Comorbidities, n (%)

Diabetes

13 (21.7)

35 (18.4)

0.713

Active malignancy

11 (18.3)

22 (11.6)

0.259

Immunocompromised

5 (8.3)

10 (5.3)

0.575

Cause of ARDS, n (%)

  

 < 0.001

Non pulmonary

4 (6.7)

–

 

Pulmonary

56 (93.3)

–

 

ARDS severity, n (%)

  

 < 0.001

Mild

3 (5.0)

–

 

Moderate

30 (50.0)

–

 

Severe

27 (45.0)

–

 

Pneumonia, n (%)

54 (90.0)

28 (14.7)

 < 0.001

Covid-19, n (%)

29 (48.3)

2 (1.1)

 < 0.001

Apache II score, median [IQR]

20 [15, 22]

21 [15, 26]

0.023

SOFA score, median [IQR]

8 [5, 12]

10 [8, 12]

0.011

LIPS, median [IQR]

6 [6, 8]

5 [3, 6]

 < 0.001

Pre-ICU LOS, days median [IQR]

2 [0, 5]

1 [0, 3]

0.227

Mechanical ventilation and gas exchange, median [IQR]

P max, cmH2O

23 [18, 28]

18 [14, 22]

 < 0.001

PEEP, cmH2O

10 [8, 12]

5 [5, 8]

 < 0.001

Driving pressure, cmH2O

12 [8, 17]

12 [8, 15]

0.458

VT, mL

518 [386, 624]

470 [402, 532]

0.162

VT/PBW, ml/kg

7.8 [6.3, 9.3]

7.1 [6.2, 8.6]

0.068

Compliance, mL/cmH2O

34.5 [24.1, 51.5]

36.8 [27.6, 57.8]

0.173

RR, breaths/min

21 [16, 28]

18 [15, 23]

0.006

PaO2/FiO2, mmHg†

105 [81, 142]

263 [169, 336]

 < 0.001

Duration MV, hours

20 [10, 32]

22 [12, 32]

0.671

Outcomes

ICU LOS, days median [IQR]

9 [6, 19]

6 [3, 11]

 < 0.001

Hospital LOS, days median [IQR]

19 [10, 31]

16 [8, 31]

0.394

ICU mortality, n (%)

25 (41.7)

60 (31.6)

0.2

30d mortality, n (%)

25 (41.7)

70 (36.8)

0.604

90d mortality, n (%)

27 (45.0)

74 (38.9)

0.495

1 year mortality, n (%)

27 (45.0)

76 (40.0)

0.592

  1. Data are presented as n (%), median [IQR] or mean (SD). P values were calculated using Chi-square, T test or Mann–Whitney U test depending on the type and distribution of the variable. PBW is calculated as: PBW male = 50 + 0·91 * (cm of height—152·4) and PBW female = 45·5 + 0·91 * (cm of height—152·4)
  2. †PF ratio worst measured in the 24 h before sampling
  3. ARDS Acute respiratory distress syndrome, BMI Body mass index, APACHE II Acute physiology and chronic health evaluation II, SOFA Sequential organ failure assessment, LIPS Lung injury prediction score, ICU Intensive care unit, LOS Length of stay, PaO2 Partial pressure of oxygen, FiO2 Fraction of inspired oxygen, MV Mechanical ventilation, PEEP Positive end-expiratory pressure, RR Respiratory rate. Vt Tidal volume, PBW Predicted body weight
Back to article page

Critical Care

ISSN: 1364-8535