Table 3 Differences in plasma biomarker levels were found when comparing patients with RIARDS to patients with persistent ARDS. Analyses adjusting for multiple comparisons showed that plasma IL-6, IL-8 and PAI-1 were significantly lower in patients with RIARDS compared to those with persistent ARDS
From: Rapidly improving ARDS differs clinically and biologically from persistent ARDS
Biomarker | Persistent ARDS N = 169 Median (IQR) | RIARDS N = 46 Median (IQR) | p value | Bonferroni adjusted p value‡ |
|---|---|---|---|---|
Biomarkers in RIARDS versus persistent ARDS | ||||
Inflammation mediators | ||||
 IL-8 (pg/ml) | 62 (17, 453) | 16 (7, 68) | 0.0001 | 0.001 |
 IL-6 (pg/ml) | 462 (83, 4704) | 80 (33, 474) | 0.0002 | 0.003 |
 TNF alpha (pg/ml) | 88 (66, 147) | 71 (62, 90) | 0.006 | 0.08 |
 IL-10 (pg/ml) | 38 (26, 103) | 28 (23, 44) | 0.007 | 0.09 |
 IFN gamma (pg/ml) | 113 (93, 145) | 106 (82, 128) | 0.05 | 0.62 |
 IL-1Beta (pg/ml) | 78 (64, 105) | 73 (56, 91) | 0.05 | 0.71 |
 CX3CL1 (pg/ml) | 13,180 (11,488, 15,440) | 11,974 (10,688, 14,626) | 0.09 | 1.0 |
 sTNFR-1 (pg/ml) | 5273 (2516, 10,436) | 4563 (1482, 10,125) | 0.20 | 1.0 |
Lung injury | ||||
Alveolar type I | ||||
 sRAGE (pg/ml) | 4579 (2495, 7535) | 3657 (2081, 7921) | 0.24 | 1.0 |
Endothelial cell | ||||
 Ang-2 (pg/ml) | 9059 (4531, 16,221) | 5569 (3397, 9435) | 0.005 | 0.06 |
 ICAM-1 (pg/ml) | 677,335 (332,593, 1,544,076) | 456,391 (280,394, 714,185) | 0.01 | 0.14 |
Coagulation | ||||
 PAI-1 (ng/ml) | 18 (5, 50) | 5 (3, 11) | 0.0001 | 0.001 |
 Protein C (% control) | 69 (33, 129) | 87 (58, 158) | 0.04 | 0.51 |