Fig. 3

Representative examples of manually (upper row) and automatically (lower row) excluded CTs. In the upper row, manual exclusion criteria were applied, including a loss of symmetry, b structural change (e.g., intracranial hemorrhage), c severe signal interference, and d chronic large brain lesion with atrophy. In the lower row, automated exclusion of CTs resulted from inaccurate registration, leading to e loss of CC segmentation, f loss of CN segmentation, g loss of both CC and CN segmentations, and h incorrect segmentation. The regions enclosed by dotted lines indicate missing ROI segmentations. CC, corpus callosum; CN, caudate nucleus