Fig. 1

Human endotoxemia induces alterations in circulating ECM neo-epitopes. Schematic depiction of the experimental human endotoxemia model (a) and the induced inflammatory response (b), derived from previously published data [15] Plasma concentrations of C1M (c), C3M (d), C4Ma3 (e), C6M (f), ELP-3 (g), X-FIB (h), and PRO-C3 (i), PRO-C4 (j) and PRO-C6 (k) were measured in 10 healthy male individuals at baseline (T0) and at 1 h, 3 h, 6 h and 24 h after LPS administration. The dotted line indicates the moment of LPS administration (immediately after T0). Data are presented as median and interquartile range. *p < 0.05; **p < 0.01; ***p < 0.001 compared with T0, calculated by Friedman test followed by post-hoc testing with Bonferroni correction. IL-6 Interleukin-6, IL-8 Interleukin-8, IL-10 Interleukin-10, TNF tumor necrosis factor, LPS lipopolysaccharide. Figure 1a and 1b were created with BioRender.com