Fig. 2

Patients with septic shock display elevated levels of circulating ECM neo-epitopes compared to healthy individuals. Plasma concentrations of C1M (a), C3M (b), C4Ma3 (c), C6M (d), ELP-3 (e), X-FIB (f), and PRO-C3 (g), PRO-C4 (h) and PRO-C6 (i) were measured in plasma samples collected at ICU admission from patients with septic shock (n = 43). Healthy control data of C3M, C4Ma3, C6M and X-FIB were obtained from the experimental human endotoxemia model at T0 (before LPS administration). Healthy control data for C1M and PRO-C4 levels were obtained from 33 healthy donors (in-house controls measured by Nordic Bioscience), and the levels of ELP-3 measured in control individuals were reported previously [19]. Each symbol represents a single individual or patient. The dotted lines represent the circulating levels in healthy individuals reported previously [19,20,21,22,23]. Data are presented as median and interquartile range. ***p < 0.001 calculated using Mann–Whitney U tests