Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study

Table 2 Circulating levels of ECM neo-epitopes weakly correlate with plasma levels of inflammatory cytokines

ICU admission	IL-10		IL-6		IL-8		TNF
ICU admission	Correlation coefficient	p value	Correlation coefficient	p value	Correlation coefficient	p value	Correlation coefficient	p value
C1M	0.225	0.147	0.080	0.611	0.242	0.118	0.214	0.169
C3M	0.344	0.043	0.179	0.304	0.348	0.041	0.492	0.003
C4Ma3	0.354	0.034	0.230	0.176	0.467	0.004	0.412	0.013
C6M	0.354	0.044	0.171	0.340	0.353	0.044	0.414	0.017
ELP-3	0.291	0.085	0.080	0.644	0.270	0.111	0.334	0.046
X-FIB	0.273	0.077	0.411	0.006	0.469	0.002	0.392	0.009
PRO-C3	0.288	0.061	0.293	0.057	0.505	0.001	0.494	0.001
PRO-C4	0.201	0.196	0.076	0.630	0.157	0.315	0.259	0.094
PRO-C6	0.171	0.298	0.259	0.112	0.199	0.224	0.335	0.037

Spearman correlation (r and p) between concentrations of inflammatory cytokines and circulating ECM neo-epitopes in septic shock patients at ICU admission. Bold values signify correlations with a p value < 0.05

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