Table 1 Baseline demographic data and cardiac arrest characteristics
Characteristics | Derivation cohort, n = 224 | Internal validation cohort, n = 96 | External validation cohort, n = 128 | P-value |
|---|---|---|---|---|
Age, years | 58 (49–67) | 58 (45–71) | 58 (42–68) | 0.90 |
Female sex | 65 (29.0) | 28 (29.2) | 27 (21.1) | 0.18 |
Preexisting illness | ||||
Coronary artery disease | 23 (10.3) | 8 (8.3) | 20 (15.6) | 0.20 |
Congestive heart disease | 7 (3.1) | 4 (4.2) | 9 (7.0) | 0.24 |
Hypertension | 55 (24.6) | 38 (39.6) | 41 (32.0) | 0.02 |
Diabetes mellitus | 47 (21.0) | 17 (17.7) | 40 (31.3) | 0.03 |
Pulmonary disease | 7 (3.1) | 6 (6.3) | 5 (3.9) | 0.41 |
Renal disease | 17 (7.6) | 8 (8.3) | 19 (14.8) | 0.09 |
Stroke | 7 (3.1) | 5 (5.2) | 6 (4.7) | 0.70 |
Malignancy | 14 (6.3) | 4 (4.2) | 6 (4.7) | 0.73 |
Cardiac arrest characteristics | ||||
Witnessed arrest | 126 (56.3) | 46 (47.9) | 83 (64.8) | 0.05 |
Bystander CPR | 132 (58.9) | 52 (54.2) | 89 (69.5) | 0.06 |
Shockable rhythm | 90 (40.2) | 31 (32.3) | 47 (36.7) | 0.39 |
Cardiac etiology | 111 (49.6) | 46 (47.9) | 56 (43.8) | 0.50 |
No flow time, min | 4.0 (1.0–8.0) | 6.0 (2.0–10.0) | 1.0 (0.0–12.8)a | 0.004 |
Low flow time, min | 21.0 (11.5–34.5) | 25.0 (15.0–42.0) | 19.0 (9.0–30.0)a | 0.009 |
Time from ROSC to scan, h | ||||
Magnetic resonance imaging | 75.0 (73.0–81.0) | 76.0 (73.0–81.0) | 78.0 (76.0–80.1)a | 0.001 |