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Table 2 Prognostic performance of specific ADC interval for poor neurological outcome in the derivation cohort

From: Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal–external validation study

ADC - R (thresholds)a

AUC (95% CI)

Cut-off value

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

P─valueb

ADC–R(600)

0.909 (0.863–0.943)

> 13.2

76.1 (68.1–82.9)

100.0 (95.8–100.0)

100

72.3 (65.9–77.8)

Reference

ADC–R(250)

0.813 (0.756–0.862)

> 0.4

45.7 (37.2–54.3)

100.0 (95.8–100.0)

100

53.4 (45.4–61.3)

< 0.001

ADC–R(300)

0.843 (0.789–0.888)

> 0.9

55.1 (46.4–63.5)

100.0 (95.8–100.0)

100

58.1 (49.7–66.2)

0.001

ADC–R(350)

0.870 (0.819–0.911)

> 1.6

65.2 (56.6–73.1)

100.0 (95.8–100.0)

100

64.2 (55.4–72.3)

0.003

ADC–R(400)

0.887 (0.838–0.925)

> 2.4

70.3 (61.9–77.8)

100.0 (95.8–100.0)

100

67.7 (58.8–75.7)

0.04

ADC–R(450)

0.894 (0.846–0.931)

> 3.6

73.9 (65.8–81.0)

100.0 (95.8–100.0)

100

70.5 (61.6–78.4)

0.07

ADC–R(500)

0.901 (0.854–0.937)

> 5.2

75.4 (67.3–82.3)

100.0 (95.8–100.0)

100

71.7 (62.7–79.5)

0.16

ADC–R(550)

0.907 (0.861–0.942)

> 7.9

76.1 (68.1–82.9)

100.0 (95.8–100.0)

100

72.3 (65.9–77.8)

0.56

ADC–R(650)

0.902 (0.855–0.937)

> 20.5

76.8 (68.9–83.6)

100.0 (95.8–100.0)

100

72.9 (66.5–78.5)

0.09

ADC–R(700)

0.890 (0.841–0.928)

> 39.6

69.6 (61.2–77.1)

100.0 (95.8–100.0)

100

67.2 (58.3–75.2)

0.02

ADC–R(750)

0.873 (0.822–0.913)

> 58.2

64.5 (55.9–72.4)

100.0 (95.8–100.0)

100

63.7 (55.0–71.8)

0.007

ADC–R(800)

0.857 (0.804–0.900)

> 71.1

63.8 (55.2–71.8)

100.0 (95.8–100.0)

100

63.2 (54.5–71.3)

0.002

ADC–R(850)

0.848 (0.794–0.892)

> 79.7

61.6 (52.9–69.7)

100.0 (95.8–100.0)

100

61.9 (53.3–70.0)

0.002

ADC–R(900)

0.842 (0.788–0.887)

> 85.4

60.9 (52.2–69.1)

100.0 (95.8–100.0)

100

61.4 (52.8–69.5)

0.002

ADC–R(950)

0.843 (0.788–0.888)

> 89.4

63.8 (55.2–71.8)

100.0 (95.8–100.0)

100

63.2 (54.5–71.3)

0.003

ADC–R(1000)

0.842 (0.787–0.887)

> 92.3

63.0 (54.4–71.1)

100.0 (95.8–100.0)

100

62.8 (54.1–70.9)

0.004

ADC–R(1050)

0.841 (0.787–0.887)

> 94.7

63.0 (54.4–71.1)

100.0 (95.8–100.0)

100

62.8 (54.1–70.9)

0.004

ADC–R(1100)

0.842 (0.788–0.887)

> 96.8

63.0 (54.4–71.1)

100.0 (95.8–100.0)

100

62.8 (54.1–70.9)

0.005

ADC–R(1150)

0.842 (0.787–0.887)

> 98.5

62.3 (53.7–70.4)

100.0 (95.8–100.0)

100

62.3 (53.7–70.4)

0.006

  1. aThe definition of ADC - R(x) is the ratio of voxels with ADC values ranging from 200 × 10−6 mm2/s to the threshold (x)
  2. bP values are based on the DeLong test for comparison of the area under the receiver operating characteristic curve (reference: ADC–R[600])
  3. ADC Apparent diffusion coefficient, AUC Area under the receiver operating characteristic curve, CI Confidence interval, PPV Positive predictive value, NPV Negative predictive value
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