Table 3 Application of cutoff values from ADC - R(450) to ADC - R(650) in the derivation cohort to the internal and external Cohorts
ADC - R(thresholds)a | Cut-off value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|
Derivation cohort | ||||||
ADC–R(450) | > 3.6 | 0.894 (0.846–0.931) | 73.9 (65.8–81.0) | 100.0 (95.8–100.0) | 100 | 70.5 (64.3–76.0) |
ADC–R(500) | > 5.2 | 0.901 (0.854–0.937) | 75.4 (67.3–82.3) | 100.0 (95.8–100.0) | 100 | 71.7 (65.4–77.2) |
ADC–R(550) | > 7.9 | 0.907 (0.861–0.942) | 76.1 (68.1–82.9) | 100.0 (95.8–100.0) | 100 | 72.3 (65.9–77.8) |
ADC–R(600) | > 13.2 | 0.909 (0.863–0.943) | 76.1 (68.1–82.9) | 100.0 (95.8–100.0) | 100 | 72.3 (65.9–77.8) |
ADC–R(650) | > 20.5 | 0.902 (0.855–0.937) | 76.8 (68.9–83.6) | 100.0 (95.8–100.0) | 100 | 72.9 (66.5–78.5) |
Internal validation cohort | ||||||
ADC–R(450) | > 3.6 | 0.886 (0.805–0.942) | 66.2 (53.7–77.2) | 100.0 (87.7–100.0) | 100 | 54.9 (46.6–62.9) |
ADC–R(500) | > 5.2 | 0.894 (0.815–0.948) | 70.6 (58.3–81.0) | 100.0 (87.7–100.0) | 100 | 58.3 (49.2–66.9) |
ADC–R(550) | > 7.9 | 0.905 (0.829–0.956) | 70.6 (58.3–81.0) | 100.0 (87.7–100.0) | 100 | 58.3 (49.2–66.9) |
ADC–R(600) | > 13.2 | 0.911 (0.835–0.959) | 70.6 (58.3–81.0) | 100.0 (87.7–100.0) | 100 | 58.3 (49.2–66.9) |
ADC–R(650) | > 20.5 | 0.909 (0.833–0.958) | 70.6 (58.3–81.0) | 100.0 (87.7–100.0) | 100 | 58.3 (49.2–66.9) |
External validation cohort | ||||||
ADC–R(450) | > 3.6 | 0.912 (0.849–0.955) | 66.7 (53.7–78.0) | 100.0 (94.5–100.0) | 100 | 75.6 (68.6–81.4) |
ADC–R(500) | > 5.2 | 0.916 (0.854–0.958) | 73.4 (60.3–83.4) | 100.0 (94.5–100.0) | 100 | 79.3 (71.8–85.2) |
ADC–R(550) | > 7.9 | 0.917 (0.855–0.958) | 74.6 (62.1–84.7) | 100.0 (94.5–100.0) | 100 | 80.2 (72.7–86.1) |
ADC–R(600) | > 13.2 | 0.918 (0.856–0.959) | 77.8 (65.5–87.3) | 100.0 (94.5–100.0) | 100 | 82.3 (74.5–88.1) |
ADC–R(650) | > 20.5 | 0.915 (0.853–0.957) | 79.4 (67.3–88.5) | 98.5 (91.7–100.0) | 98.0 (87.7–99.7) | 83.1 (75.2–88.9) |