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Fig. 1 | Critical Care

Fig. 1

From: ACE inhibitors and angiotensin receptor blockers differentially alter the response to angiotensin II treatment in vasodilatory shock

Fig. 1

Schematic Diagram of the Classical RAS Axis and the Mechanism of ACEi and ARB medications. Renin catalyzes the conversion of angiotensinogen to angiotensin-I, which in turn is converted to angiotensin-II by ACE. Angiotensin-II primarily exerts its cardiovascular effects by stimulating the AT1R. ACEi medications act by inhibiting the conversion of the angiotensin-I to angiotensin-II. ARB medications act by directly antagonizing AT1R. Ang angiotensin, ACE angiotensin-converting enzyme, ACEi ACE-inhibitor, ARB angiotensin receptor blocker, AT1R angiotensin-II type-1 receptor, RAS renin-angiotensin system

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Critical Care

ISSN: 1364-8535