Skip to main content

Table 2 Association of RASS with respiratory drive in marginalized two-part models

From: Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome

Model specification

Model AICa

Percent change in PES0.1 per 1-unit change in RASS

95% CI for RASS

p value for RASS

RASS only

336.3

5.9%

− 2.9 to 15.5%

0.19

Core multivariable model adjusting for mechanics, chemoreceptor input, and sedation deptha

318.9

9.2%

− 0.5 to 19.7%

0.06

Core multivariable modelb plus angiopoetin-2c

312.4

11.7%

2.5–21.7%

0.01

Core multivariable modelb plus interleukin-6c

320.2

11.4%

0.7% to 23.4%

0.04

Core multivariable modelb plus interleukin-8c

317.4

12.9%

2.6–24.3%

0.01

  1. aAIC refers to Akaike information criterion, an index of how well the model fits the data. AIC is calculated from the model’s maximum likelihood and includes a penalty for increasing the number of independent variables in the model. Lower AIC signifies better model fit
  2. bCore multivariable model includes the following covariates: tidal volume per predicted body weight, end-inspiratory transpulmonary pressure, end-expiratory transpulmonary pressure, pH, PaCO2, PaO2, Richmond agitation-sedation score (RASS)
  3. cCoefficients for biomarkers in this model are presented in Table 2. Angiopoietin-2 and IL-8 were also significantly associated with PES0.1
Back to article page

Critical Care

ISSN: 1364-8535