Table 1 Characteristics of patients

Age (years)

57.5 [50.75;67]

58 [51.75;72.75]

66 [57;71.5]

0.38

Male sex

17/24 (71%)

10/18 (56%)

8/11 (73%)

0.56

Chronic pulmonary disease

3/24 (12%)

9/18 (50%)

6/11 (55%)

 < 0.01

COPD

3/24 (12%)

5/18 (28%)

4/11 (36%)

0.2

Asthma

0/24 (0%)

4/18 (22%)

1/11 (9.1%)

0.03

Current smoking

4/24 (17%)

4/18 (22%)

3/11 (27%)

0.75

Chronic kidney disease

0/16 (0%)

1/18 (5.6%)

0/11 (0%)

1

Obesity

5/23 (22%)

5/18 (28%)

1/11 (9.1)

1

Diabetes mellitus

4/23 (17%)

3/18 (17%)

1/11 (9.1%)

1

Heart coronary disease

6/24 (25%)

4/18 (22%)

6/11 (55%)

0.18

High blood pressure

7/16 (44%)

6/18 (33%)

4/11 (36%)

0.92

Immunodepression

4/24 (17%)

0/18 (0%)

2/11 (18%)

0.11

Long-term systemic corticosteroids

1/24 (4.2%)

1/18 (5.6%)

0/11 (0%)

1

Antibiotics before admission

5/16 (31%)

3/10 (30%)

1/10 (10%)

0.5

Antifungals before admission

0/16 (0%)

0/10 (0%)

0/10 (0%)

1

PPI

2/24 (8.3%)

0/10 (0%)

1/11 (9.1%)

1

Metformin

1/23 (4.3%)

1/17 (5.9%)

1/11 (9.1%)

1

SAPS 2

47.5 [35.5;56.75]

45 [31.25;57.5]

68.5 [53.5;86]

0.08

Heart rate (/min)

91 [80;108]

98.5 [73;110.75]

90 [80;116]

0.85

Respiratory rate (/min)

26 [25.25;29.75]

25.5 [22.25;28]

32.5 [24.75;40]

0.22

Mean blood pressure (mmHg)

85 [78;97]

86.5 [78.5;101]

84 [78.75;93.25]

0.92

PaO2/FiO2

140 [132;204]

150 [121.7;206.2]

120 [91;144.5]

0.19

Neutrophils count (/mm³)

8340 [5227;11160]

4980 [3412;7750]

7460 [2465;10935]

0.07

Lymphocytes count (/mm³)

660 [540;862.5]

750 [402.5;1142.5]

340 [225;1070]

0.6

Fibrinogen (g/L)

9.6 [8.55;9.9]

6.5 [6.125;8.25]

7.7 [5.2;9.6]

0.06

CRP (mg/L)

189 [116;286]

47 [41;1,006]

159 [101;214]

0.15

Septic shock

11/24 (46%)

3/18 (17%)

7/11 (64%)

0.026

Acute kidney injury

6/16 (38%)

5/18 (28%)

6/11 (55%)

0.37

Day 28 survival

19/24 (79%)

15/18 (83%)

7/11 (64%)

0.48