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  1. Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI...

    Authors: Nicolas Nesseler, Alexandre Mansour, Matthieu Schmidt, Marylou Para, Alizée Porto, Pierre-Emmanuel Falcoz, Nicolas Mongardon, Claire Fougerou, James T. Ross, Antoine Beurton, Lucie Gaide-Chevronnay, Pierre-Grégoire Guinot, Guillaume Lebreton, Erwan Flecher, André Vincentelli and Nicolas Massart
    Citation: Critical Care 2024 28:54
  2. Current recommendations support guiding fluid resuscitation through the assessment of fluid responsiveness. Recently, the concept of fluid tolerance and the prevention of venous congestion (VC) have emerged as...

    Authors: Felipe Muñoz, Pablo Born, Mario Bruna, Rodrigo Ulloa, Cecilia González, Valerie Philp, Roberto Mondaca, Juan Pablo Blanco, Emilio Daniel Valenzuela, Jaime Retamal, Francisco Miralles, Pedro D. Wendel-Garcia, Gustavo A. Ospina-Tascón, Ricardo Castro, Philippe Rola, Jan Bakker…
    Citation: Critical Care 2024 28:52

    The Matters Arising to this article has been published in Critical Care 2024 28:167

    The Matters Arising to this article has been published in Critical Care 2024 28:83

  3. There is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase) has been shown to exert reno-protective properties, although it remai...

    Authors: Niklas Bruse, Katerina Pardali, Maarten Kraan, Matthijs Kox and Peter Pickkers
    Citation: Critical Care 2024 28:50
  4. Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site of infection in ...

    Authors: Jayesh Dhanani, Jason A. Roberts, Antoine Monsel, Antoni Torres, Marin Kollef and Jean-Jacques Rouby
    Citation: Critical Care 2024 28:49
  5. Tracheal intubation is a high-risk intervention commonly performed in critically ill patients. Due to its favorable cardiovascular profile, ketamine is considered less likely to compromise clinical outcomes. T...

    Authors: Takatoshi Koroki, Yuki Kotani, Takahiko Yaguchi, Taisuke Shibata, Motoki Fujii, Stefano Fresilli, Mayuko Tonai, Toshiyuki Karumai, Todd C. Lee, Giovanni Landoni and Yoshiro Hayashi
    Citation: Critical Care 2024 28:48
  6. Trauma burden is one of the leading causes of young human life and economic loss in low- and middle-income countries. Improved emergency and trauma care systems may save up to 2 million lives in these countries.

    Authors: Dinesh Bagaria, Amila S. Ratnayake, Aireen Madrid and Tamara J. Worlton
    Citation: Critical Care 2024 28:47
  7. Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their use to counteract life-threatening hypotension comes with po...

    Authors: Julian Arias-Ortiz and Jean-Louis Vincent
    Citation: Critical Care 2024 28:46
  8. Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. Howev...

    Authors: Nicole P. Juffermans, Tarik Gözden, Karim Brohi, Ross Davenport, Jason P. Acker, Michael C. Reade, Marc Maegele, Matthew D. Neal and Philip C. Spinella
    Citation: Critical Care 2024 28:45

    The Matters Arising to this article has been published in Critical Care 2024 28:135

  9. Patients undergoing cardiac surgery are subject to infectious complications that adversely affect outcomes. Rapid identification is essential for adequate treatment. Procalcitonin (PCT) is a noninvasive blood ...

    Authors: Davide Nicolotti, Silvia Grossi, Valeria Palermo, Federico Pontone, Giuseppe Maglietta, Francesca Diodati, Matteo Puntoni, Sandra Rossi and Caterina Caminiti
    Citation: Critical Care 2024 28:44
  10. Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.

    Authors: Paul Gabarre, Cyrielle Desnos, Alexandra Morin, Louai Missri, Tomas Urbina, Vincent Bonny, Matthieu Turpin, Jean-Luc Baudel, Laurence Berard, Melissa Montil, Bertrand Guidet, Guillaume Voiriot, Jérémie Joffre, Eric Maury and Hafid Ait-Oufella
    Citation: Critical Care 2024 28:43

    The Matters Arising to this article has been published in Critical Care 2024 28:79

  11. Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of qSOFA 1 remains controversial. We investiga...

    Authors: Maria Evangelia Adami, Antigone Kotsaki, Nikolaos Antonakos, Efthymia Giannitsioti, Stamatios Chalvatzis, Maria Saridaki, Christina Avgoustou, Karolina Akinosoglou, Konstantina Dakou, Georgia Damoraki, Konstantina Katrini, Panagiotis Koufargyris, Vasileios Lekakis, Antonia Panagaki, Asimina Safarika, Jesper Eugen-Olsen…
    Citation: Critical Care 2024 28:42

    The Matters Arising to this article has been published in Critical Care 2024 28:190

    The Matters Arising to this article has been published in Critical Care 2024 28:161

  12. This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.

    Authors: Jacob Vine, John H. Lee, Max S. Kravitz, Anne V. Grossestreuer, Lakshman Balaji, Shannon B. Leland, Noa Berlin, Ari Moskowitz and Michael W. Donnino
    Citation: Critical Care 2024 28:41
  13. Ventilator associated pneumonia (VAP) due to wild-type AmpC-producing Enterobacterales (wtAE) is frequent in intensive care unit (ICU) patients. Despite a low level of evidence, definitive antimicrobial therap...

    Authors: Matthieu Petit, Frank Bidar, Quentin Fosse, Lucie Lefevre, Marine Paul, Tomas Urbina, Paul Masi, Florent Bavozet, Jérémie Lemarié, Etienne de Montmollin, Chloé Andriamifidy-Berti, Julien Dessajan, Benjamin Zuber, Lara Zafrani, Edwige Peju, Paris Meng…
    Citation: Critical Care 2024 28:40
  14. Volume replacement with crystalloid fluid is the conventional treatment of hemorrhage. We challenged whether a standardized amount of 5% or 20% albumin could be a viable option to maintain the blood volume dur...

    Authors: François Jardot, Robert G. Hahn, Dominique Engel, Christian M. Beilstein and Patrick Y. Wuethrich
    Citation: Critical Care 2024 28:39
  15. The optimal feeding strategy for critically ill patients is still debated, but feeding must be adapted to individual patient needs. Critically ill patients are at risk of muscle catabolism, leading to loss of ...

    Authors: Renée Blaauw, Philip C. Calder, Robert G. Martindale and Mette M. Berger
    Citation: Critical Care 2024 28:38
  16. Authors: Aiko Tanaka, Tetsuhisa Kitamura, Akinori Uchiyama, Yusuke Enokidani, Yukiko Koyama, Takeshi Yoshida and Yuji Fujino
    Citation: Critical Care 2024 28:37

    The original article was published in Critical Care 2023 27:378

    The original article was published in Critical Care 2023 27:395

  17. Sepsis is a severe condition characterized by acute organ dysfunction resulting from an imbalanced host immune response to infections. Apolipoprotein H (APOH) is a critical plasma protein that plays a crucial ...

    Authors: Zhicai Yu, Changxue Xiao, Rong Liu, Dandan Pi, Bian Jin, Zhen Zou and Feng Xu
    Citation: Critical Care 2024 28:36
  18. Post-traumatic stress has been identified as a frequent long-term complication in survivors of critical illnesses after sepsis. Little is known about long-term trajectories of post-traumatic stress and potenti...

    Authors: Konrad F. R. Schmidt, Jochen S. Gensichen, Maya Schroevers, Martina Kaufmann, Friederike Mueller, Gustav Schelling, Sabine Gehrke-Beck, Monique Boede, Christoph Heintze, Michel Wensing and Daniel Schwarzkopf
    Citation: Critical Care 2024 28:35
  19. Our understanding of post-ICU recovery is influenced by which patients are selected to study and treat. Many studies currently list an ICU length of stay of at least 24, 48, or 72 h as an inclusion criterion. ...

    Authors: Dylan Flaws, John F. Fraser, Kevin Laupland, Jayshree Lavana, Sue Patterson, Alexis Tabah, Oystein Tronstad and Mahesh Ramanan
    Citation: Critical Care 2024 28:34
  20. The ultra-low-frequency pressure reactivity index (UL-PRx) has been established as a surrogate method for bedside estimation of cerebral autoregulation (CA). Although this index has been shown to be a predicto...

    Authors: Paolo Gritti, Marco Bonfanti, Rosalia Zangari, Ezio Bonanomi, Alessia Farina, Giulio Pezzetti, Isabella Pelliccioli, Luca Longhi, Maria Di Matteo, Andrea Viscone, Gabriele Lando, Gaia Cavalleri, Simonetta Gerevini, Francesco Biroli and Ferdinando Luca Lorini
    Citation: Critical Care 2024 28:33
  21. The aim of this multicentre prospective observational study was to identify the incidence, patient characteristics, diagnostic pathway, management and outcome of acute mesenteric ischaemia (AMI).

    Authors: Annika Reintam Blaser, Merli Mändul, Martin Björck, Stefan Acosta, Miklosh Bala, Zsolt Bodnar, Dumitru Casian, Zaza Demetrashvili, Mario D’Oria, Virginia Durán Muñoz-Cruzado, Alastair Forbes, Hanne Fuglseth, Moran Hellerman Itzhaki, Benjamin Hess, Karri Kase, Mikhail Kirov…
    Citation: Critical Care 2024 28:32

    The Matters Arising to this article has been published in Critical Care 2024 28:85

    The Matters Arising to this article has been published in Critical Care 2024 28:67

  22. There is conflicting evidence on association between quick sequential organ failure assessment (qSOFA) and sepsis mortality in ICU patients. The primary aim of this study was to determine the association betwe...

    Authors: Andrew Li, Lowell Ling, Hanyu Qin, Yaseen M. Arabi, Sheila Nainan Myatra, Moritoki Egi, Je Hyeong Kim, Mohd Basri Mat Nor, Do Ngoc Son, Wen-Feng Fang, Bambang Wahyuprajitno, Madiha Hashmi, Mohammad Omar Faruq, Boonsong Patjanasoontorn, Maher Jaffer Al Bahrani, Babu Raja Shrestha…
    Citation: Critical Care 2024 28:30

    The Matters Arising to this article has been published in Critical Care 2024 28:59

  23. Sepsis is a life-threatening syndrome characterized by acute loss of organ function due to infection. Sepsis survivors are at risk for long-term comorbidities, have a reduced Quality of Life (QoL), and are pro...

    Authors: Erik C. N. Luijks, Elisabeth C. van der Slikke, Arthur R. H. van Zanten, Jan C. ter Maaten, Maarten J. Postma, Henk B. M. Hilderink, Robert H. Henning and Hjalmar R. Bouma
    Citation: Critical Care 2024 28:29
  24. Following resuscitated out-of-hospital cardiac arrest (OHCA), inflammatory markers are significantly elevated and associated with hemodynamic instability and organ dysfunction. Vasopressor support is recommend...

    Authors: Laust E. R. Obling, Rasmus P. Beske, Martin A. S. Meyer, Johannes Grand, Sebastian Wiberg, Thomas Mohr, Anders Damm-Hejmdal, Julie L. Forman, Ruth Frikke-Schmidt, Fredrik Folke, Jacob E. Møller, Jesper Kjaergaard and Christian Hassager
    Citation: Critical Care 2024 28:28
  25. Exclusive enteral nutrition (EN) is often observed during the first week of ICU admission because of the extra costs and safety considerations for early parenteral nutrition. This study aimed to assess the ass...

    Authors: Yizhe Chen, Zirui Liu, Qiuhui Wang, Fei Gao, Hongyang Xu, Lu Ke, Zheng-Yii Lee, Christian Stoppe, Daren K. Heyland, Fengming Liang and Jiajia Lin
    Citation: Critical Care 2024 28:26
  26. Delivering higher doses of protein to mechanically ventilated critically ill patients did not improve patient outcomes and may have caused harm. Longitudinal urea measurements could provide additional informat...

    Authors: Ryan W. Haines, John R. Prowle, Andrew Day, Danielle E. Bear, Daren K. Heyland and Zudin Puthucheary
    Citation: Critical Care 2024 28:24
  27. The use of the passive leg raising (PLR) is limited in acute brain injury (ABI) patients with increased intracranial pressure (ICP) since the postural change of the head may impact on ICP and cerebral autoregu...

    Authors: Antonio Messina, Agnieszka Uryga, Alberto Giardina, Pietro Ciliberti, Denise Battaglini, Nicolo’ Patroniti, Marek Czosnyka, Xavier Monnet, Maurizio Cecconi and Chiara Robba
    Citation: Critical Care 2024 28:23
  28. The “Blood Pressure and Oxygenation Targets in Post Resuscitation Care” (BOX) trial investigated whether a low versus high blood pressure target, a restrictive versus liberal oxygenation target, and a shorter ...

    Authors: Martin A. S. Meyer, Christian Hassager, Simon Mølstrøm, Britt Borregaard, Johannes Grand, Benjamin Nyholm, Laust E. R. Obling, Rasmus P. Beske, Anna Sina P. Meyer, Ditte Bekker‑Jensen, Matilde Winther-Jensen, Vibeke L. Jørgensen, Henrik Schmidt, Jacob E. Møller and Jesper Kjaergaard
    Citation: Critical Care 2024 28:20
  29. During control mechanical ventilation (CMV), the driving pressure of the respiratory system (ΔPrs) serves as a surrogate of transpulmonary driving pressure (ΔPlung). Expiratory muscle activity that decreases end-...

    Authors: Vaia Stamatopoulou, Evangelia Akoumianaki, Katerina Vaporidi, Efstathios Stamatopoulos, Eumorfia Kondili and Dimitrios Georgopoulos
    Citation: Critical Care 2024 28:19
  30. Sepsis and trauma are known to disrupt gut bacterial microbiome communities, but the impacts and perturbations in the fungal (mycobiome) community after severe infection or injury, particularly in patients exp...

    Authors: Gwoncheol Park, Jennifer A. Munley, Lauren S. Kelly, Kolenkode B. Kannan, Robert T. Mankowski, Ashish Sharma, Gilbert Upchurch, Gemma Casadesus, Paramita Chakrabarty, Shannon M. Wallet, Robert Maile, Letitia E. Bible, Bo Wang, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron…
    Citation: Critical Care 2024 28:18
  31. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor and plays a critical role in the immune response. TREM-1 activation leads to the production and release of proinflamm...

    Authors: Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner and Markus Alexander Weigand
    Citation: Critical Care 2024 28:17
  32. A recent large multicentre trial found no difference in clinical outcomes but identified a possibility of increased mortality rates in patients with acute kidney injury (AKI) receiving higher protein. These al...

    Authors: Zheng-Yii Lee, Ellen Dresen, Charles Chin Han Lew, Julia Bels, Aileen Hill, M. Shahnaz Hasan, Lu Ke, Arthur van Zanten, Marcel C. G. van de Poll, Daren K. Heyland and Christian Stoppe
    Citation: Critical Care 2024 28:15
  33. The impact of therapeutic plasma exchange (TPE) on short-term mortality in adult patients with sepsis-induced organ dysfunction remains uncertain. The objective of the study is to assess the effect of adjunct ...

    Authors: Vladimir Kuklin, Michael Sovershaev, Johan Bjerner, Philip Keith, L. Keith Scott, Owen Matthew Truscott Thomas, Wladimir Szpirt, Gail Rock and Bernd Stegmayr
    Citation: Critical Care 2024 28:12
  34. Authors: George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul McCarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell…
    Citation: Critical Care 2024 28:11

    The original article was published in Critical Care 2023 27:432

  35. In this study including 391 critically ill patients with nosocomial pneumonia due to Gram-negative pathogens, combination therapy was not associated with a reduced hazard of death at Day 28 or a greater likeli...

    Authors: François Barbier, Claire Dupuis, Niccolò Buetti, Carole Schwebel, Élie Azoulay, Laurent Argaud, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Jean-Marie Forel, Christophe Adrie, Étienne de Montmollin, Jean Reignier, Stéphane Ruckly, Jean-Ralph Zahar…
    Citation: Critical Care 2024 28:10